LoopWHI ’26

Kidney Health

biomarkers
8,059 reports with creatinine, 7,197 with blood urea and 7,986 with uric acid, from employees and covered family members

Key takeaways

  • Most creatinine and urea reports were below the cutoffs used here. Only 1.0% of creatinine reports were above 1.3 mg/dL, and 0.2% of blood-urea reports were above 50 mg/dL.
  • 16.8% of uric-acid reports were above the sex-specific cutoffs used here, above 6 mg/dL in women and above 7 in men: 22.1% of men's reports against 10.3% of women's. Against 1.0% for creatinine and 0.2% for urea, it is the common finding on this page.
  • Among men the share peaked at ages 30–39, at 25.7%, while among women it kept climbing to 27.2% at 60 and above. From age 50 onwards a larger share of women than of men was above cutoff.
  • Where both tests appear in the same report, HbA1c of 5.7% or above was found in 44.2% of above-cutoff uric-acid reports, against 36.2% of the rest. Both tests appear in the same 5,936 reports; nothing here shows that one result causes the other.

Most creatinine and urea reports were below the cutoffs#

Of 8,059 creatinine results, 80 were above 1.3 mg/dL. Blood urea was lower still, with 15 results above 50 mg/dL out of 7,197. The third kidney-related marker on the same panels behaves differently: 1,342 of 7,986 uric-acid results were above the cutoff applied to them.

Marker and report cutoff Above cutoff Reports above Reports tested
Serum creatinine, above 1.3 mg/dL 1.0% 80 8,059
Blood urea, above 50 mg/dL 0.2% 15 7,197
Uric acid, above 6 mg/dL in women and above 7 mg/dL in men 16.8% 1,342 7,986

Those 8,059 creatinine reports divide as follows.

Serum creatinine Share of reports Reports
1.3 mg/dL or below 99.0% 7,979
Above 1.3, up to and including 1.5 mg/dL 0.6% 45
Above 1.5 mg/dL 0.4% 35

These are test reports from insured employees and covered family, not unique people or a representative workforce sample. Each test has its own base. Results exactly at a cutoff are not counted as above it. Methodology.

Mean creatinine in men was 0.87 mg/dL in WHI 2025 and 0.91 mg/dL here. The earlier sample described professionals, while this edition includes covered family; the difference does not establish a change in kidney health. WHI 2025 published no uric-acid or blood-urea figures.

Creatinine above the cutoff was about fourteen times as common at 60 and above as in the 20s#

Results above the cutoff were about fourteen times as common at 60 and above as in the 20s: 4.1% against 0.3%. The share was higher in each successive adult age band, and the absolute numbers stay small throughout: the oldest band's 4.1% is 25 reports.

Raised creatinine by age

Serum creatinine >1.3 mg/dL.

View data table
Age Above 1.3 mg/dL Reports above Reports tested
20–29 0.3% 7 2,427
30–39 0.4% 12 2,957
40–49 1.3% 15 1,120
50–59 2.4% 21 867
60+ 4.1% 25 616
Group Above 1.3 mg/dL Reports above Reports tested
Employee 0.6% 32 5,283
Covered family member 1.7% 48 2,776

About one in five male uric-acid reports exceeded the cutoff, against one in ten female reports#

22.1% of men's uric-acid reports were above 7 mg/dL, and 10.3% of women's were above 6 mg/dL. The male share is 2.1 times the female one.

Raised uric acid by sex
Women
Men

Women: >6 mg/dL. Men: >7 mg/dL.

View data table
Group Report cutoff Above cutoff Reports above Reports tested
Women above 6 mg/dL 10.3% 370 3,582
Men above 7 mg/dL 22.1% 972 4,404

The two shares are measured against two different lines. A ratio between them is not a comparison of how much uric acid men and women carry. It is a comparison of how often each group crosses its own laboratory threshold. The means compare concentrations in the same units, and they run the same way: 6.07 mg/dL across the 4,404 men's reports against 4.59 across the 3,582 women's.

Pooled across both sexes, the share above the sex-specific cutoffs does not climb steadily with age. It is higher in the 30s than in the 40s or 50s, and highest at 60 and above.

Age Above cutoff Reports above Reports tested
20–29 16.1% 388 2,415
30–39 18.3% 537 2,937
40–49 15.3% 169 1,105
50–59 13.0% 111 854
60+ 21.7% 131 604

The combined figure hides different age patterns in male and female reports.

Loop Takes

High uric acid can coexist with impaired kidney function, but high uric acid by itself may not tell us how good or bad kidney health is. It has a tendency to deposit in different joints of the body, leading to gouty arthritis, a condition that really compromises quality of life. Uric acid is one of the waste products eliminated through the kidneys, but a high result does not necessarily point directly to impaired kidney function.

Dr Amruta Bakshi

Metabolic Health Expert

Loop Health

Men's uric-acid share peaks in their 30s; women's keeps rising to 27.2% at 60 and above#

Among men, the share above cutoff was highest at ages 30–39: 25.7% of 1,726 reports. Among women it was highest at the other end of the age range, 27.2% at 60 and above. Between the 40s and the 50s the two lines cross.

Uric acid above cutoff by age and sex
MenWomen

Men: uric acid >7 mg/dL. Women: >6 mg/dL.

View data table
Age Men above 7 mg/dL Men's reports Women above 6 mg/dL Women's reports
20–29 23.5% 1,353 6.6% 1,062
30–39 25.7% 1,726 7.8% 1,211
40–49 19.5% 652 9.3% 453
50–59 9.5% 348 15.4% 506
60+ 15.8% 292 27.2% 312

Men's share does not simply fall with age. It rises to the 30s, drops to its lowest in the 50s, then rises again at 60 and above. Women's rises in every band. Because the sexes are held to different cutoffs, the crossover means something precise: from age 50, a larger share of women exceeded 6 mg/dL than of men exceeded 7.

One study offers context for the female pattern, from outside this data. Among 7,662 US women aged 20 and over in a national health survey, serum uric acid after menopause was higher than before it once age, weight, diet, alcohol, kidney function, hypertension and diuretic use were accounted for, by 0.34 mg/dL after natural menopause and 0.36 after surgical menopause; women currently using postmenopausal hormones ran 0.24 mg/dL lower than those who were not. The authors concluded that the rise in women's uric acid with age may be explained by menopause and other age-related factors. That is a different population and a different measure from the shares above, and these reports record no menopausal status. Hak and Choi, Arthritis Research & Therapy, 2008.

The older bands are much smaller than the younger ones, with 348 male reports at 50–59 against 1,726 in the 30s, so their shares move on fewer results. Every band is made of people who came for a test, and the bands exclude 70 reports from people under 20 and one report with no recorded age.

Men's uric-acid share is above women's in all five metros, furthest apart in Pune#

In all five metros, men's reports were above cutoff more often than women's, and the widest split was in Pune, at 22.6% against 7.6%.

Raised uric acid across five metros
MenWomen
Bengaluru
Delhi NCR
Pune
Hyderabad
Mumbai

Men: >7 mg/dL. Women: >6 mg/dL.

View data table
Reporting area Men above 7 mg/dL Men's reports Women above 6 mg/dL Women's reports
Bengaluru 25.7% 1,066 11.3% 862
Delhi NCR 24.8% 423 13.3% 338
Pune 22.6% 1,444 7.6% 1,096
Hyderabad 19.0% 258 6.8% 221
Mumbai 18.3% 611 12.7% 560

Across these five areas the male share spans 7.4 points, from Mumbai's 18.3% to Bengaluru's 25.7%. In four of the five, the gap between men and women is wider than that whole spread.

Mumbai is the exception, and the two figures behind it pull in opposite directions: it has the lowest male share of the five and the second-highest female share. The highest female share is Delhi NCR's, at 13.3%.

These five pincode-based reporting areas cover 6,879 of the 7,986 uric-acid reports. The shares describe tested reports, not city populations.

Elevated blood sugar was more common in reports with high uric acid: 44.2% against 36.2%#

In the 5,936 reports that carry both tests, elevated blood sugar was found in 44.2% of those above the uric-acid cutoff and in 36.2% of the rest, a gap of 7.9 percentage points.

Elevated blood sugar by uric-acid result
Above cutoff
At or below cutoff
View data table
Uric acid in the same report HbA1c 5.7% or above Reports at or above Reports with both tests
Above cutoff 44.2% 428 969
At or below cutoff 36.2% 1,800 4,967

The comparison needs both results in the same report, so it leaves out 2,050 of the 7,986 uric-acid reports, which carried no paired HbA1c result.

Two results appearing together in one report is co-occurrence, not a chain of cause and effect: the biomarker file is not linked to any individual record over time, so nothing here establishes that either result led to the other.

The comparison group is not a healthy baseline. More than a third of reports with a normal uric-acid result already had an HbA1c of 5.7% or above, so the 7.9-point gap sits on top of that floor rather than rising from zero.

What to check in kidney testing and follow-up#

The two markers on this page that describe filtration are each read against one fixed line. The two tests that would describe it properly, an eGFR and a urine albumin-to-creatinine ratio, are already recommended at least annually for everyone with diagnosed type 2 diabetes. These reports carry markers rather than diagnoses, so that list comes from a provider's records, not from this analysis. The American Diabetes Association's 2026 standard records that kidney disease in diabetes typically develops after about ten years in type 1, most often five to fifteen years from diagnosis, but may already be present at the diagnosis of type 2.

For context on why the kidney is worth an employer's attention at all even when these markers are low: a meta-analysis of community-based Indian studies puts chronic kidney disease prevalence at 13.2% among people aged 15 and above.

References

  1. 1Kidney Disease: Improving Global Outcomes. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International (2024). Source.
  2. 2American Diabetes Association Professional Practice Committee. 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2026. Diabetes Care 49 (Supplement 1), S246 (2026). Source.
  3. 3FitzGerald, J.D. and colleagues. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care & Research 72, 744–760 (2020). doi:10.1002/acr.24180.
  4. 4Hak, A.E. and Choi, H.K. Menopause, postmenopausal hormone use and serum uric acid levels in US women – The Third National Health and Nutrition Examination Survey. Arthritis Research & Therapy 10, R116 (2008). doi:10.1186/ar2519.
  5. 5Jordan, D.M. and colleagues. No causal effects of serum urate levels on the risk of chronic kidney disease: a Mendelian randomization study. PLOS Medicine 16, e1002725 (2019). doi:10.1371/journal.pmed.1002725.
  6. 6Talukdar, R. and colleagues. Chronic Kidney Disease Prevalence in India: a systematic review and meta-analysis from community-based representative evidence between 2011 to 2023. Nephrology 30, e14420 (2025). doi:10.1111/nep.14420.
  7. 7Singh, A.K. and colleagues. Epidemiology and risk factors of chronic kidney disease in India: results from the SEEK (Screening and Early Evaluation of Kidney Disease) study. BMC Nephrology 14, 114 (2013). doi:10.1186/1471-2369-14-114.